Fluconazole reduced the rate of recurrence of vulvovaginal candidiasis.

Patients: 387 women >18 years of age (mean age 34 y, 67% white) who had active, acute candida vaginitis (severity score >3), a positive result on microscopic examination of vaginal secretions, >4 episodes of candida vaginitis in the previous 12 months, and were clinically cured (severity score ,3) at 14 days after receiving 3 sequential doses of fluconazole, 150 mg, at 72 hour intervals. Exclusion criteria: lack of confirmation of microscopic findings by culture, pregnancy, mixed infections or known seropositivity for HIV, or use of antifungal agents in the previous 4 weeks.